Project 561
Sodium Arsenite Studies in p53 +/- Mice
$242,259
Principal Investigator
Raymond Tice
Project Manager
Jarmila Popovicova
Contractor
Integrated Laboratory Systems, Inc.
Research Impact
Evaluates the carcinogenicity of sodium arsenite as a function of hepatic methyl donor status. Also investigates the ability of sodium arsenite to promote bladder carcinogenicity and skin carcinogenicity as a function of hepatic methyl donor availability. Reports findings from investigations using heterozygous p53 deficient male mice receiving chronic administrations of arsenic in drinking water. Research partner: USEPA and ACWA. Published in 2000.
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