The goal of this research was to investigate the use of DNA microarrays as a bioanalytical tool for analysis of pharmaceuticals in treated waters that are intended for reuse. The results suggest that prototypic pharmaceuticals target molecular events associated with pharmaceutical-induced gene induction and repression in exposed organisms. Gene expression profiles can be evaluated as a means to discern pharmaceutical exposure. When fully developed, such a bioanalytical approach may provide an efficient and robust method for screening pharmaceuticals in reuse and other water matrices. Published by WERF. 100 pages. Soft cover and online and PDF. (2007)
Originally funded as WERF project 01-HHE-21T.