As more water agencies plan to diversify their water supply portfolios with alternative water sources, strategies are needed to manage integration of these sources into existing drinking water systems and to mitigate any adverse impacts. This project prepared a literature review, established a framework for identifying distribution system and customer premise plumbing water quality impacts, and applied the framework to test corrosion and biological growth with potable reuse water. Guidance is provided to help utilities maintain distribution system water quality while integrating new supplies and strategies. Research partners: California State Water Resources Control Board and Metropolitan Water District of Southern California. Published in 2023.