Project 326
Identification of Mutagenic By-products From Aquatic Humic Chlorination
$177,380
Principal Investigator
Russell Christman
Project Manager
Martin J Allen
Contractor
University of North Carolina at Chapel Hill
Research Impact
Identifies chemical structures and concentrations of reaction products of chlorine and humic acids responsible for the mutagenic response of drinking water residues in the Ames histidine reversion assay with strain TA1000. Also evaluates Ames tester strains TA97, 102, and 104 for measuring mutagenicity of humic chlorination by-products. Uses the TOX method to chemically track halogen substitution and to identify major components of TOX that show positive responses in the Ames reversion assay. Published in 1990.
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